Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Scientific and Data Coordinating Center (U24 - Clinical Trial Not Allowed) | RFA DK 22 503

Opportunity Information: Apply for RFA DK 22 503

This funding opportunity (RFA-DK-22-503) is a limited competition cooperative agreement from the National Institutes of Health focused on extending the Chronic Renal Insufficiency Cohort (CRIC) Study by continuing support for its Scientific and Data Coordinating Center (SDCC). CRIC is a large, multi-center, prospective observational cohort study that follows men and women living with chronic kidney disease (CKD). The study is designed to track kidney health and related outcomes over time, with a strong emphasis on understanding how CKD progresses and how it connects with cardiovascular disease and other complications. Because this is a continuation-focused, limited competition announcement, it is aimed at sustaining and advancing an established national research resource rather than launching a new clinical trial or an unrelated project.

The SDCC is positioned as the operational and scientific hub for the next phase of CRIC. While the CRIC Clinical Centers will handle participant follow-up under a separate funding announcement, this FOA concentrates on the SDCCs responsibilities across the entire consortium. That includes leading study-wide coordination, maintaining consistency in data collection and management, supporting the steering and governance structure of the study group, and helping ensure the next project period meets its scientific goals. A notable feature of the upcoming work is the emphasis on completing enrollment into ongoing sub-studies that rely on at-home assessments of kidney and cardiovascular function. In practical terms, this means the SDCC will be expected to support logistics and data workflows for remote or home-based measurements, ensuring that protocols, quality control, and data integration are strong enough to produce reliable research-grade information across multiple sites.

A major objective in this announcement is long-term sustainability and broad scientific access. The SDCC is expected not only to manage the data and coordinate analyses during the project period, but also to develop and implement a durable strategy for disseminating CRIC data and biological samples to the wider research community. This typically implies building or improving systems for documentation, metadata, data dictionaries, standard operating procedures, and user support so outside investigators can understand and responsibly use CRIC resources. In addition, the FOA highlights a clear federal expectation for stewardship and archiving: all study data and samples must be properly archived in the NIDDK Central Repository. That requirement points to a strong emphasis on curation, standardization, and compliance with repository policies so the cohort continues to be a high-value, reusable national asset long after the funded period ends.

Administratively, this opportunity uses the cooperative agreement mechanism (U24), meaning NIH will have substantial involvement in guiding and overseeing the work compared with a standard grant. It is also explicitly labeled Clinical Trial Not Allowed, reflecting that the scope is coordinating and supporting an observational cohort and related infrastructure rather than testing interventions in a trial framework. The original application due date listed in the source data is October 27, 2022, and the award ceiling is $650,000. The opportunity is listed under CFDA number 93.847 and falls within a health-related activity category.

Eligibility is restricted in ways consistent with a limited competition continuation. The announcement specifies that non-U.S. entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. The source data also lists eligible applicants as small businesses, though the full announcement would be the authoritative place to confirm the exact eligible applicant types and any additional constraints typical of limited competition renewals. Overall, the opportunity is best understood as NIH/NIDDKs mechanism for keeping the CRIC coordinating infrastructure strong, modernizing and supporting remote sub-study activities, and ensuring that CRIC data and biospecimens are curated, archived, and shared in a way that maximizes their long-term impact on CKD and cardiovascular research.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Scientific and Data Coordinating Center (U24 - Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2022-07-21.
• Applicants must submit their applications by 2022-10-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $650,000.00 in funding.
• Eligible applicants include: Small businesses.

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