Opportunity Information: Apply for PA 17 100
The National Institutes of Health (NIH) funding opportunity titled "HIV-1 infection of the Central Nervous System (R01)" (Funding Opportunity Number: PA-17-100) supports research projects that investigate how HIV-1 affects the brain and central nervous system (CNS) in the modern treatment era, where many people are on antiretroviral therapy (ART) and have suppressed virus in the blood. The central idea is that even with effective ART, a meaningful number of individuals living with HIV experience neurological and neurobehavioral problems, and the NIH is seeking studies that clarify the biological mechanisms behind these outcomes and point toward actionable therapeutic targets.
A major emphasis of this announcement is understanding pathogenic mechanisms of HIV-1 induced CNS dysfunction specifically under conditions of viral suppression and ongoing ART, rather than focusing only on untreated infection. Applicants are expected to address why CNS-related complications can persist despite systemic control of HIV, including how HIV or HIV-related inflammation may continue to influence brain function, neurocognitive performance, mood, behavior, and other neurological outcomes. The FOA is designed to stimulate work that can connect mechanistic findings to real-world clinical issues faced by people living with HIV, with the longer-term goal of reducing or preventing HIV-associated neurological and neurobehavioral comorbidities.
The opportunity also explicitly encourages research aimed at identifying therapeutic targets, meaning biological pathways, cellular processes, viral reservoirs, immune responses, or other modifiable drivers of CNS injury or dysfunction that could be used to design treatments or preventive strategies. In practice, this invites projects that move beyond describing associations and toward clarifying causality and intervention points. Both basic science and translational research are responsive, allowing applicants to propose laboratory-based mechanistic studies, human-centered clinical or observational work, or integrated approaches that bridge model systems and patient samples. Studies may be conducted in domestic (U.S.-based) or international settings, reflecting an interest in findings that are relevant across diverse populations and healthcare contexts.
While multidisciplinary teams and collaborative alliances are encouraged, they are not required. This means proposals can come from individual laboratories or single institutions, but applicants are also welcome to assemble cross-disciplinary expertise (for example, neuroimmunology, virology, neuroimaging, clinical neurology, psychiatry, biomarker discovery, computational biology, or pharmacology) when that strengthens the science. The grant mechanism is an NIH R01, which typically supports hypothesis-driven research projects with clearly defined aims and a structured plan for generating new knowledge and, ideally, translating that knowledge into intervention opportunities.
Eligibility is broad and includes many types of U.S. organizations and governmental units, such as state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); and tribal organizations other than federally recognized governments. The FOA also allows applications from nonprofits (both 501(c)(3) and non-501(c)(3)), public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), small businesses, and other eligible entities. In addition, the announcement highlights several categories of "other eligible applicants" to underscore inclusion of a wide range of institutions and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations).
In terms of administrative details drawn from the source information, the opportunity is categorized as discretionary funding and uses the grant funding instrument. The activity category is listed under education and health, and the associated CFDA numbers include 93.242, 93.273, 93.279, 93.853, 93.855, 93.856, and 93.866. The posting indicates a creation date of 2017-01-05 and lists an original closing date of 2020-05-07. Award ceiling and expected awards are not specified in the provided source data.
Overall, this FOA is aimed at pushing the field toward a clearer, modern understanding of HIV-associated CNS complications in the ART era and toward practical therapeutic directions, supporting rigorous basic-to-translational research that can explain persistent neurologic risk and reduce the burden of neurobehavioral and neurological comorbidities for people living with HIV.Apply for PA 17 100
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HIV-1 infection of the Central Nervous System (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.279, 93.853, 93.855, 93.856, 93.866.
- This funding opportunity was created on 2017-01-05.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Health
Next opportunity: Office of Special Education and Rehabilitative Services (OSERS): Office of Special Education Programs (OSEP): State Personnel Development Grants (SPDG) Program CFDA Number 84.323A
Previous opportunity: Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 17 100
Applicants also applied for:
Applicants who have applied for this opportunity (PA 17 100) also looked into and applied for these:
| Funding Opportunity |
|---|
| Neuroscience Research on Drug Abuse (R01) Apply for PA 17 111 Funding Number: PA 17 111 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Neuroscience Research on Drug Abuse (R21) Apply for PA 17 112 Funding Number: PA 17 112 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R21) Apply for PA 17 109 Funding Number: PA 17 109 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Chronic Condition Self-Management in Children and Adolescents (R01) Apply for PA 17 115 Funding Number: PA 17 115 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30) Apply for PAR 17 121 Funding Number: PAR 17 121 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 17 117 Funding Number: PA 17 117 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 17 118 Funding Number: PA 17 118 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chronic Condition Self-Management in Children and Adolescents (R21) Apply for PA 17 116 Funding Number: PA 17 116 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R01) Apply for PA 17 110 Funding Number: PA 17 110 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) Apply for PA 17 120 Funding Number: PA 17 120 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Mechanisms of Brain Development Mediating Substance Use and Dependence (R01) Apply for PA 17 119 Funding Number: PA 17 119 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Perception and Cognition Research to Inform Cancer Image Interpretation (R21) Apply for PAR 17 124 Funding Number: PAR 17 124 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Perception and Cognition Research to Inform Cancer Image Interpretation (R01) Apply for PAR 17 125 Funding Number: PAR 17 125 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Quantitative Imaging Tools and Methods for Cancer Therapy Response Assessment (UG3/UH3) Apply for PAR 17 128 Funding Number: PAR 17 128 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Quantitative Imaging Tools and Methods for Cancer Response Assessment (U01) Apply for PAR 17 129 Funding Number: PAR 17 129 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R21) Apply for PA 17 137 Funding Number: PA 17 137 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R01) Apply for PA 17 136 Funding Number: PA 17 136 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NINR Clinical Trial Planning Grant (R34) Apply for PAR 17 133 Funding Number: PAR 17 133 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRCs) (U54) Apply for RFA NS 17 021 Funding Number: RFA NS 17 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,200,000 |
| Activities to Promote Technology Research Collaborations (APTRC) for Cancer Research (Admin Supp) Apply for PA 17 143 Funding Number: PA 17 143 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 17 100", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.