Opportunity Information: Apply for PA 17 100
The National Institutes of Health (NIH) funding opportunity titled "HIV-1 infection of the Central Nervous System (R01)" (Funding Opportunity Number: PA-17-100) supports research projects that investigate how HIV-1 affects the brain and central nervous system (CNS) in the modern treatment era, where many people are on antiretroviral therapy (ART) and have suppressed virus in the blood. The central idea is that even with effective ART, a meaningful number of individuals living with HIV experience neurological and neurobehavioral problems, and the NIH is seeking studies that clarify the biological mechanisms behind these outcomes and point toward actionable therapeutic targets.
A major emphasis of this announcement is understanding pathogenic mechanisms of HIV-1 induced CNS dysfunction specifically under conditions of viral suppression and ongoing ART, rather than focusing only on untreated infection. Applicants are expected to address why CNS-related complications can persist despite systemic control of HIV, including how HIV or HIV-related inflammation may continue to influence brain function, neurocognitive performance, mood, behavior, and other neurological outcomes. The FOA is designed to stimulate work that can connect mechanistic findings to real-world clinical issues faced by people living with HIV, with the longer-term goal of reducing or preventing HIV-associated neurological and neurobehavioral comorbidities.
The opportunity also explicitly encourages research aimed at identifying therapeutic targets, meaning biological pathways, cellular processes, viral reservoirs, immune responses, or other modifiable drivers of CNS injury or dysfunction that could be used to design treatments or preventive strategies. In practice, this invites projects that move beyond describing associations and toward clarifying causality and intervention points. Both basic science and translational research are responsive, allowing applicants to propose laboratory-based mechanistic studies, human-centered clinical or observational work, or integrated approaches that bridge model systems and patient samples. Studies may be conducted in domestic (U.S.-based) or international settings, reflecting an interest in findings that are relevant across diverse populations and healthcare contexts.
While multidisciplinary teams and collaborative alliances are encouraged, they are not required. This means proposals can come from individual laboratories or single institutions, but applicants are also welcome to assemble cross-disciplinary expertise (for example, neuroimmunology, virology, neuroimaging, clinical neurology, psychiatry, biomarker discovery, computational biology, or pharmacology) when that strengthens the science. The grant mechanism is an NIH R01, which typically supports hypothesis-driven research projects with clearly defined aims and a structured plan for generating new knowledge and, ideally, translating that knowledge into intervention opportunities.
Eligibility is broad and includes many types of U.S. organizations and governmental units, such as state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); and tribal organizations other than federally recognized governments. The FOA also allows applications from nonprofits (both 501(c)(3) and non-501(c)(3)), public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), small businesses, and other eligible entities. In addition, the announcement highlights several categories of "other eligible applicants" to underscore inclusion of a wide range of institutions and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations).
In terms of administrative details drawn from the source information, the opportunity is categorized as discretionary funding and uses the grant funding instrument. The activity category is listed under education and health, and the associated CFDA numbers include 93.242, 93.273, 93.279, 93.853, 93.855, 93.856, and 93.866. The posting indicates a creation date of 2017-01-05 and lists an original closing date of 2020-05-07. Award ceiling and expected awards are not specified in the provided source data.
Overall, this FOA is aimed at pushing the field toward a clearer, modern understanding of HIV-associated CNS complications in the ART era and toward practical therapeutic directions, supporting rigorous basic-to-translational research that can explain persistent neurologic risk and reduce the burden of neurobehavioral and neurological comorbidities for people living with HIV.Apply for PA 17 100
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HIV-1 infection of the Central Nervous System (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.279, 93.853, 93.855, 93.856, 93.866.
- This funding opportunity was created on 2017-01-05.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH Funding Opportunity PA-17-100 - HIV-1 infection of the Central Nervous System (R01)
1) What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity titled "HIV-1 infection of the Central Nervous System (R01)" with Funding Opportunity Number PA-17-100. It uses the NIH R01 grant mechanism to support research projects focused on how HIV-1 affects the brain and central nervous system (CNS), especially in the modern treatment era.
2) What is the main goal of PA-17-100?
The main goal is to support studies that explain why neurological and neurobehavioral problems can persist in people living with HIV even when they are on antiretroviral therapy (ART) and have suppressed virus in the blood. The NIH is looking for research that clarifies biological mechanisms and points toward actionable therapeutic targets.
3) Why does the FOA emphasize the "modern treatment era"?
The announcement emphasizes conditions of viral suppression and ongoing ART because many individuals now have controlled HIV in the blood, yet a meaningful number still experience CNS-related complications. The FOA prioritizes understanding pathogenic mechanisms that operate despite systemic viral control, rather than focusing only on untreated infection.
4) What kinds of CNS outcomes does this FOA care about?
The FOA highlights outcomes related to brain function and CNS dysfunction, including neurocognitive performance, mood, behavior, and other neurological or neurobehavioral problems experienced by people living with HIV.
5) What does "pathogenic mechanisms" mean in the context of this FOA?
In this FOA, "pathogenic mechanisms" refers to the biological processes that drive HIV-1 induced CNS dysfunction under ART and viral suppression. This includes understanding how HIV or HIV-related inflammation may continue to influence the brain and contribute to persistent neurological risk.
6) Is this FOA focused on associations or on cause-and-effect?
It is designed to stimulate research that moves beyond describing associations and toward clarifying mechanisms, causality, and intervention points. The FOA encourages projects that can connect mechanistic findings to real-world clinical issues and identify modifiable drivers of CNS injury or dysfunction.
7) What does the FOA mean by "therapeutic targets"?
"Therapeutic targets" refers to biological pathways, cellular processes, viral reservoirs, immune responses, or other modifiable drivers of CNS injury or dysfunction that could be used to design treatments or preventive strategies aimed at reducing or preventing HIV-associated neurological and neurobehavioral comorbidities.
8) What types of research approaches are considered responsive?
Both basic science and translational research are responsive. This can include laboratory-based mechanistic studies, human-centered clinical or observational work, or integrated approaches that bridge model systems with patient samples.
9) Does the FOA require multidisciplinary or collaborative teams?
No. Multidisciplinary teams and collaborative alliances are encouraged, but they are not required. Applications can come from individual laboratories or single institutions, but applicants may also assemble cross-disciplinary expertise when it strengthens the proposed science.
10) What kinds of expertise might be helpful for an application?
The FOA notes that cross-disciplinary expertise can strengthen a proposal, with examples such as neuroimmunology, virology, neuroimaging, clinical neurology, psychiatry, biomarker discovery, computational biology, and pharmacology.
11) Where can studies be conducted?
Studies may be conducted in domestic (U.S.-based) or international settings. This reflects interest in findings that are relevant across diverse populations and healthcare contexts.
12) What is the funding mechanism and instrument?
The mechanism is an NIH R01. The funding instrument is listed as a grant, and the opportunity is categorized as discretionary funding.
13) What types of organizations are eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governmental units, including state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; and private institutions of higher education.
14) Are nonprofits eligible?
Yes. The FOA allows applications from nonprofits, including both 501(c)(3) and non-501(c)(3) organizations.
15) Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
16) Are tribal governments and tribal organizations eligible?
Yes. The FOA includes Native American tribal governments (federally recognized) and tribal organizations other than federally recognized governments among eligible applicants.
17) Are specific institution types highlighted as eligible?
Yes. The announcement highlights a range of "other eligible applicants," including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and faith-based or community-based organizations.
18) Are U.S. territories and non-U.S. entities eligible?
Yes. The highlighted eligible applicant categories include U.S. territories or possessions and non-U.S. entities (foreign organizations).
19) Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among the highlighted "other eligible applicants."
20) What is the activity category listed for this opportunity?
The activity category is listed under education and health.
21) What CFDA numbers are associated with this funding opportunity?
The associated CFDA numbers listed are 93.242, 93.273, 93.279, 93.853, 93.855, 93.856, and 93.866.
22) What are the key dates provided in the source information?
The posting indicates a creation date of 2017-01-05 and lists an original closing date of 2020-05-07.
23) Are the award ceiling and number of expected awards provided?
No. The provided source data does not specify an award ceiling or the expected number of awards.
24) What is the long-term intent behind the research supported by this FOA?
The longer-term intent is to reduce or prevent HIV-associated neurological and neurobehavioral comorbidities by improving the modern understanding of HIV-related CNS complications in the ART era and identifying practical therapeutic directions.
25) Does this FOA only support work on untreated HIV infection?
No. A major emphasis is on CNS dysfunction under conditions of viral suppression and ongoing ART. The FOA is specifically designed to address why CNS-related complications may persist despite systemic control of HIV.
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