Opportunity Information: Apply for RFA DK 16 504
The grant opportunity titled "Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)" is a National Institutes of Health (NIH) cooperative agreement intended to support continued work within the long-running TEDDY epidemiological study. TEDDY focuses on understanding environmental and other determinants that contribute to diabetes development in children, and this announcement is specifically designed to keep the study infrastructure moving forward so that enrolled children can continue to be followed over time and so that valuable biological samples can continue to be used for advanced immunological research.
A central feature of this opportunity is that it is a limited competition. Rather than being open to the broader research community, the FOA invites an application only from the Program Director/Principal Investigator of the current TEDDY Data Coordinating Center (DCC). The rationale is that the DCC has been embedded in the consortium since the beginning and already holds the operational knowledge, systems, and continuity required to manage complex longitudinal follow-up, coordinate multi-site activities, and maintain the integrity of data and biospecimen processes. In practical terms, the NIH is prioritizing continuity of leadership and infrastructure because TEDDY data and samples are uniquely valuable, and disruptions in coordination could jeopardize long-term scientific utility.
The primary purpose of the funding is to enable the TEDDY DCC to continue following TEDDY participants (the "TEDDY children") and to support downstream collaborative studies that use TEDDY samples to measure and analyze immune markers. That means the award is aimed at maintaining and extending the backbone functions that make TEDDY useful as a platform for immunological discovery: ongoing participant follow-up, continued data capture and management, and biosample acquisition and tracking. By ensuring the cohort remains well-characterized over time, the DCC makes it possible for researchers to test new hypotheses about immune development, immune dysregulation, and early biological signals associated with diabetes-related outcomes using consistently collected, well-documented specimens.
This FOA uses a cooperative agreement mechanism (UC4), which signals that NIH expects substantial involvement in the conduct of the work beyond what is typical for a standard research grant. Cooperative agreements are commonly used for large, complex, multi-center programs where NIH program staff play an active partnership role in oversight, coordination, and strategic direction. In the context of TEDDY, that generally aligns with the need for harmonized procedures, standardized data and specimen governance, and coordinated decision-making across participating entities and investigators.
From an administrative standpoint, the opportunity is categorized as discretionary funding and falls under NIH activity areas connected to food and nutrition and health. The CFDA numbers associated with the announcement are 93.847, 93.855, and 93.856, reflecting NIH program areas relevant to diabetes and related biomedical research. The eligible applicant type listed is public and state-controlled institutions of higher education, consistent with the typical institutional home for a major data coordinating center that manages large-scale research operations.
Eligibility is also constrained by restrictions on non-U.S. applicants. Non-domestic (non-U.S.) entities, meaning foreign institutions, are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization. However, foreign components are allowed as defined by the NIH Grants Policy Statement, which generally means that while the prime applicant must be a U.S.-based eligible institution, certain project elements may involve foreign collaborations or performance sites when appropriately justified and compliant with NIH policy. This structure allows the project to maintain U.S.-based stewardship of the award while still permitting international scientific contributions when they are part of the overall research enterprise.
The announcement was created on December 15, 2016, and had an original closing date of March 15, 2017. NIH anticipated making a single award (expected awards: 1), reinforcing the idea that this is meant to fund the existing TEDDY DCC as the sole coordinating hub rather than create multiple competing centers. Although an award ceiling is referenced, the specific dollar amount is not provided in the supplied source text, suggesting applicants would need to consult the full FOA for budget limits, allowable costs, and any cost-sharing or budget format requirements.
Overall, this funding opportunity is best understood as NIH support for sustaining and extending a critical national research resource. It is designed to preserve continuity in TEDDY participant follow-up and to ensure that the data and biospecimen infrastructure remains strong enough to support sophisticated immunological assessments. The end result NIH is aiming for is a well-maintained longitudinal cohort and a coordinated data and sample ecosystem that enables investigators to continue generating insights into immune markers and early biological pathways relevant to diabetes in children.Apply for RFA DK 16 504
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847, 93.855, 93.856.
- This funding opportunity was created on 2016-12-15.
- Applicants must submit their applications by 2017-03-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)."
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What kind of award mechanism is being used?
The announcement uses a cooperative agreement mechanism (UC4), meaning NIH expects substantial involvement in the conduct, oversight, coordination, and strategic direction of the work compared with a typical research grant.
What does "limited competition" mean for this FOA?
This is not an open competition for the broader research community. The FOA invites an application only from the Program Director/Principal Investigator (PD/PI) of the current TEDDY Data Coordinating Center (DCC).
Who is eligible to apply?
Eligibility is limited to the PD/PI of the current TEDDY Data Coordinating Center (DCC). The eligible applicant type listed is public and state-controlled institutions of higher education.
Are non-U.S. organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply as the applicant organization.
Are foreign components allowed in any way?
Yes. Foreign components are allowed as defined by the NIH Grants Policy Statement. This generally means the prime applicant must be an eligible U.S.-based institution, while specific project elements may involve foreign collaborations or performance sites when appropriately justified and compliant with NIH policy.
What is the overall purpose of this funding?
The primary purpose is to maintain and extend the TEDDY study infrastructure so enrolled children can continue to be followed over time and biological samples can continue to be used for advanced immunological research.
What is TEDDY, and why is it important here?
TEDDY is a long-running epidemiological study focused on understanding environmental and other determinants that contribute to diabetes development in children. This FOA is designed to sustain the coordinating infrastructure that keeps TEDDY data and biospecimens usable and scientifically valuable over the long term.
What specific activities does the FOA support?
Based on the provided information, the award supports continued follow-up of TEDDY participants (the "TEDDY children"), continued data capture and management, and biosample acquisition and tracking, as well as support for collaborative studies that use TEDDY samples for immune marker measurement and analysis.
What role does the TEDDY Data Coordinating Center (DCC) play under this opportunity?
The DCC is positioned as the operational hub that manages complex longitudinal follow-up, coordinates multi-site activities, and maintains the integrity of data and biospecimen processes. NIH is prioritizing continuity because the DCC has been embedded in the consortium since the beginning and holds the operational knowledge and systems needed to avoid disruption.
Why is NIH prioritizing continuity instead of opening this to new applicants?
The rationale given is that TEDDY data and samples are uniquely valuable, and disruptions in coordination could jeopardize long-term scientific utility. Limiting eligibility to the current DCC leadership is intended to protect continuity of operations, data integrity, and biospecimen governance.
How does this funding relate to immunological research?
A key goal is to enable downstream collaborative studies that use TEDDY biospecimens to measure and analyze immune markers. Maintaining consistent follow-up and well-documented specimens supports testing hypotheses about immune development, immune dysregulation, and early biological signals associated with diabetes-related outcomes.
What kind of NIH involvement should applicants expect under a UC4 cooperative agreement?
The UC4 mechanism indicates NIH program staff are expected to play an active partnership role. In this context, that aligns with harmonized procedures, standardized data and specimen governance, and coordinated decision-making across participating entities and investigators.
How many awards does NIH expect to make?
NIH anticipated making a single award (expected awards: 1), consistent with funding the existing TEDDY DCC as the coordinating hub rather than creating multiple coordinating centers.
What are the relevant CFDA numbers for this opportunity?
The CFDA numbers associated with the announcement are 93.847, 93.855, and 93.856.
How is this opportunity categorized in terms of funding type and activity areas?
It is categorized as discretionary funding and falls under NIH activity areas connected to food and nutrition and health.
When was the announcement created, and what was the original closing date?
The announcement was created on December 15, 2016, and had an original closing date of March 15, 2017.
Is the maximum award amount (award ceiling) provided in the information given?
An award ceiling is referenced, but the specific dollar amount is not provided in the supplied information. Applicants would need to consult the full FOA for budget limits, allowable costs, and related budget requirements.
What outcomes is NIH aiming for with this award?
NIH is aiming to preserve continuity in TEDDY participant follow-up and maintain a coordinated data and sample ecosystem robust enough to support sophisticated immunological assessments, enabling continued discovery of immune markers and early biological pathways relevant to diabetes in children.
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