Opportunity Information: Apply for RFA PS 22 001
Implementing Pre-exposure Prophylaxis for HIV Prevention in Syringe Service Programs (RFA PS 22 001) is a CDC cooperative agreement funding opportunity focused on building and testing practical ways to expand HIV prevention for people who inject drugs (PWID) by integrating HIV pre-exposure prophylaxis (PrEP) navigation into syringe service programs (SSPs). The central idea is that SSPs already serve as trusted, low-barrier points of contact for PWID, and the CDC wants to strengthen "combined prevention" by making PrEP easier to start and easier to stay on through routine, navigator-supported workflows at SSP sites. Rather than funding basic science, the NOFO is aimed at implementation research that evaluates how well this approach works in real-world SSP settings and what changes are needed to make it more effective.
The project is framed as effectiveness-implementation research, meaning applicants are expected to study both outcomes and the process of delivering the intervention. On the outcomes side, the goal is to improve PrEP initiation and retention among adult PWID. On the implementation side, the work should examine whether a navigator-enhanced PrEP service bundle is acceptable to clients and feasible for SSPs to deliver, and then use findings to optimize the model. In practice, this typically implies studying questions like: What navigation activities help PWID move from interest to a prescription? What barriers show up around insurance, identification, lab work, transportation, stigma, competing priorities, or unstable housing? What staffing and training are needed at SSPs? Which referral partnerships (clinics, pharmacies, telehealth providers) actually work smoothly? How do programs keep people engaged in follow-up visits and ongoing medication access?
A key requirement is that the recipient organization must include or partner with multiple and diverse SSPs. The CDC is signaling that the work should not be limited to a single site or a narrow SSP type, but instead should be designed to generate lessons that can be applied across different SSP contexts (for example, SSPs of different sizes, geographies, operational models, and client populations). The broader intent is to help SSPs incorporate PrEP navigation and related support into their standard processes, rather than treating PrEP as an add-on that only works with special resources or unusual conditions.
The award is issued by the Department of Health and Human Services, Centers for Disease Control and Prevention, and uses a cooperative agreement mechanism. That generally indicates substantial programmatic involvement by the CDC during the project period, such as collaboration on planning, technical assistance, performance expectations, and dissemination of findings. The funding activity category is Health, and the CFDA numbers listed are 93.084 and 93.941. The NOFO anticipated a single award (ExpectedAwards: 1) with an award ceiling of $625,000.
Eligibility is broad and includes many types of entities: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other entities as described in the opportunity’s additional eligibility language. This broad eligibility fits the reality that SSPs and their partners can be housed in many different organizational structures, and that meaningful implementation research often requires partnerships among service providers, public health agencies, clinical providers, and academic evaluators.
In terms of policy alignment, the NOFO explicitly ties the work to national HIV priorities, particularly the HIV National Strategic Plan (2021-2025) and the Ending the HIV Epidemic in the U.S. initiative, specifically the "Prevent" pillar. That matters because the project is not just about improving services at a few sites; it is intended to produce applied research findings that strengthen scalable HIV prevention approaches for PWID, a population that can face elevated HIV risk and significant barriers to accessing traditional healthcare systems.
Administratively, the opportunity was created on October 28, 2021, with an original closing date of January 18, 2022, and electronic applications were due by 5:00 pm ET on the deadline date. Overall, the grant is designed to support a multi-SSP partnership that can implement, study, and refine a navigator-supported PrEP service bundle in SSP environments, producing evidence about what works, what is workable, and what it takes to sustain PrEP initiation and ongoing use among adult PWID.Apply for RFA PS 22 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Implementing Pre-exposure Prophylaxis for HIV Prevention in Syringe Service Programs" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084, 93.941.
- This funding opportunity was created on Oct 28, 2021.
- Applicants must submit their applications by Jan 18, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $625,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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