Opportunity Information: Apply for RFA AG 17 056
Understanding the Effects of ApoE2 on the Interaction between Aging and Alzheimers Disease (R01) is a National Institutes of Health grant opportunity from the Department of Health and Human Services (Funding Opportunity Number RFA-AG-17-056) that supports research aimed at explaining how the APOE2 genetic variant influences aging and Alzheimers disease (AD). ApoE2 is widely viewed as a relatively protective APOE variant compared with other common forms, and this funding call is centered on turning that observation into clear biological mechanisms. The emphasis is not only on what ApoE2 does in the brain, but also on how it may shape aging across the body and how signals between organs could affect brain health and AD risk.
The scientific scope is broad and includes descriptive, basic, and translational studies. In practice, that means projects can range from careful characterization work (for example, mapping ApoE2-associated changes in cell types, pathways, or biomarkers over the lifespan) to mechanistic laboratory studies (such as experiments that test how ApoE2 alters inflammation, lipid transport, synaptic function, vascular integrity, proteostasis, or amyloid/tau-related processes) and on toward translational efforts that begin connecting those mechanisms to clinically useful tools. A key theme is the APOE2-aging-AD relationship: applicants are expected to tackle how ApoE2 affects normal or "healthy" brain aging and how those effects intersect with the biological processes that lead to AD and age-related cognitive decline.
Another central concept in the announcement is tissue interaction and cross talk. The FOA explicitly invites work that considers the brain alongside other organs and systems involved in aging, recognizing that AD-related biology can be influenced by peripheral factors such as metabolism, immune function, vascular health, and systemic inflammation. Studies might therefore examine how ApoE2 affects communication between the central nervous system and peripheral tissues, and whether those interactions help explain resilience to neurodegeneration or slower cognitive decline in some individuals. The expectation is that the strongest projects will generate mechanistic insights that are not limited to a single narrow pathway, but instead clarify how protective biology emerges across cells, circuits, and potentially multiple organs during aging.
From an outcomes perspective, the NIH is looking for research that can point to practical next steps for the field. Specifically, the FOA highlights the identification of prognostic and diagnostic markers as well as therapeutic targets for AD and other age-related cognitive disorders. In other words, beyond advancing basic understanding, proposed studies should be positioned to reveal measurable indicators of risk or protection (biomarkers that could help predict outcomes or track disease-related changes) and to uncover actionable intervention points that could be pursued in later-stage translational or clinical research. The long-term vision described is that ApoE2-focused discoveries could ultimately support strategies to prevent or delay AD onset and potentially confer protection against multiple age-related conditions, not just dementia.
Administratively, this is an R01 grant mechanism in the health research area (CFDA 93.866). The opportunity was created on Oct 25, 2016, with an original closing date of Feb 10, 2017. The award ceiling is listed as $300,000, and the program anticipated making about 7 awards. Eligibility is expansive, including many types of domestic organizations such as state, county, and local governments; public and private institutions of higher education; nonprofit organizations with and without 501(c)(3) status; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; for-profit organizations (other than small businesses); and small businesses, with additional eligibility details referenced in the full announcement.
Overall, this funding opportunity is designed to push the ApoE2 story beyond association and into causation: explaining how and where ApoE2 exerts protective effects during aging, how those effects reshape vulnerability to Alzheimers pathology, and which measurable markers or druggable targets emerge from that biology. The program is explicitly forward-looking, aiming to build a mechanistic foundation that can later be leveraged for diagnostics, risk stratification, and interventions that improve brain aging and reduce the burden of AD and related disorders.Apply for RFA AG 17 056
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Understanding the Effects of ApoE2 on the Interaction between Aging and Alzheimers Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Oct 25, 2016.
- Applicants must submit their applications by Feb 10, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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